Top arrow pointing up

Resources

Resources

A compact, high resolution energy, and emittance diagnostic for electron beams using active plasma lenses

Jun 11, 2020. Publications

Abstract

Radiotherapy is the current standard of care for more than 50% of all cancer patients. Improvements in radiotherapy (RT) technology have increased tumor targeting and normal tissue sparing. Radiations at ultra-high dose rates required for FLASH-RT effects have sparked interest in potentially providing additional differential therapeutic benefits. We present a new experimental platform that is the first one to deliver petawatt laser-driven proton pulses of 2 MeV energy at 0.2 Hz repetition rate by means of a compact, tunable active plasma lens beamline to biological samples. Cell monolayers grown over a 10 mm diameter field were exposed to clinically relevant proton doses ranging from 7 to 35 Gy at ultra-high instantaneous dose rates of 107 Gy/s. Dose-dependent cell survival measurements of human normal and tumor cells exposed to LD protons showed significantly higher cell survival of normal-cells compared to tumor-cells for total doses of 7 Gy and higher, which was not observed to the same extent for X-ray reference irradiations at clinical dose rates. These findings provide preliminary evidence that compact LD proton sources enable a new and promising platform for investigating the physical, chemical and biological mechanisms underlying the FLASH effect.

DOI: https://doi.org/10.1063/5.0005114

More From Publications

May 2, 2024    Publications

Observation of Monoenergetic Electrons from Two-Pulse Ionization Injection in Quasilinear Laser Wakefields

M. W. von der Leyen ,1,3,* J. Holloway,1 Y. Ma,2 P. T. Campbell ,2 R. Aboushelbaya,1 Q. Qian ,2 A. F. Antoine ,2 M....

Read more

Apr 1, 2024    Publications

Ultra-intense femtosecond laser interactions with aligned nanostructures

Jorge J. Rocca,1,2,* Maria G. Capeluto,1,3 Reed C. Hollinger,1 Shoujun Wang,1 Yong Wang,1 G. Ravindra Kumar,4 Amit D....

Read more

Apr 1, 2024    Publications

Differentiating multi‐MeV, multi‐ion spectra with CR‐39 solid‐state nuclear track detectors

M. S. Schollmeier1*, J. J. Bekx1, J. Hartmann1, E. Schork1, M. Speicher1, A. F. Brodersen1, A. Fazzini1, P. Fischer1,...

Read more

Dec 20, 2023    Publications

Flexible tape-drive target system for secondary high-intensity laser-driven sources

G. Zeraouli, D. A. Mariscal, R. Hollinger, S. Zahedpour Anaraki, E. N. Folsom, E. Grace, D. Rusby, M. P. Hill, G. J....

Read more

Dec 7, 2023    Publications

The acceleration of a high-charge electron bunch to 10 GeV in a 10-cm nanoparticle-assisted wakefield accelerator

Constantin Aniculaesei, Thanh Ha, Samuel Yoffe, Lance Labun, Stephen Milton, Edward McCary, Michael M. Spinks, Hernan...

Read more

Nov 30, 2023    Publications

Nanoscale reshaping of resonant dielectric microstructures by light-driven explosions

Maxim R. Shcherbakov, Giovanni Sartorello, Simin Zhang, Joshua Bocanegra, Melissa Bosch, Michael Tripepi, Noah...

Read more